Why Trump is at higher risk for more serious illness from unpredictable COVID-19
President Donald Trump was transferred from the White House to Walter Reed Medical Center on Friday evening, the same day he and First Lady Melania Trump tested positive for the coronavirus.
Trump’s medical regime has highlighted the fact that the president is part of a group at high risk for more serious illness from COVID-19, the illness caused by SARS-CoV-2, observers said. He received a dose of REGN from Regeneron Pharmaceuticals Inc.,
experimental cocktail of neutralizing antibodies, in addition to GILD from Gilead Sciences Inc.,
The president has also been given supplemental oxygen and dexamethasone at least once, according to Dr. Sean Conley, Trump’s doctor. Six months after the start of the pandemic, there are very few treatments available for patients with COVID-19, and if a vaccine becomes available, it is unlikely to be ready until 2021. At a conference of Press Sunday, Conley first confirmed that the president had received oxygen support, at least once.
His diagnosis came hours after the White House announced that Senior Assistant Hope Hicks had tested positive after traveling with the President several times over the past week. Trump, 74, has a statistically higher risk of serious complications from the virus that has killed more than 200,000 people in the United States, analysis of hospitalization data in several countries over the past six months has shown. Obesity is another potential complication of a virus that Trump has described as “horrible” and “deadly”.
Also see:“I didn’t feel so good. I feel a lot better now. ‘ Trump tweets Walter Reed Medical Center video address
Both of these factors increase the risk for people diagnosed with the disease. According to the Centers of Disease Control and Prevention: Having obesity increases the risk of serious illness of COVID-19, and can triple the risk of hospitalization. The unpredictable virus path is related to immune function and reduces lung capacity and reserve and can make ventilation more difficult. As the body mass index increases, the risk of death from COVID-19 increases, he added.
“People in their sixties and sixties are, in general, more at risk for serious illness than people in their fifties,” the federal agency said. However, the president is not in the age group most at risk: “The greatest risk of serious illness from COVID-19 is among people aged 85 or older. There are also other factors that can increase your risk for serious illness, such as underlying health issues, ”the CDC said. “As you get older, your risk of being hospitalized for COVID-19 increases. “
How obese is the president?
The president is in the lowest risk category for obesity, according to the latest data on his weight and publicly available information on his height. Trump has a BMI of 30.1 based on a height of 6 feet, 3 inches and a weight of 243 pounds, as written in a note from his Conley last year. This gives him a BMI of 30.1 and places him in the lowest of the three stages of obesity, according to the official definition of the CDC.
BMI calculates weight, muscle, fat, and bone based on height and gender. A BMI of 25 to 29.9 is considered overweight and those with a BMI of 30 or more are considered obese; people with morbid obesity have a BMI of 44.9 or more. “Patients who received invasive mechanical ventilation were more likely to be men, to be obese” according to this study in the New England Journal of Medicine.
Research on COVID-related deaths shows that most of these people are over 70 years old. The genes in the body that appear to be a major factor in allowing the virus to access heart cells become more active with age.
Age is another risk factor. Research on COVID-related deaths shows the majority of these people are over 70 years old. Genes in the body that appear to be a major factor giving SARS-CoV-2, the virus that causes COVID-19, access to heart cells become more active with age, according to a study published in August in the Journal of Molecular and Cellular Cardiology. The coronavirus spike protein binds to certain enzymes and proteins in the heart that are more common as we age.
Inflammation in older people can be more intense, causing organ damage, according to Johns Hopkins University. “Lung tissue becomes less elastic over time, making respiratory illnesses like COVID-19 of particular concern to the elderly. The CDC added, “Eight of the 10 COVID-19-related deaths reported in the United States are in adults aged 65 and older. However, the risk of dying from COVID-19 increases more for people 85 and older.
It takes much longer to recover from the disease in the elderly, studies show, but the virus can be pernicious in how it affects people and what symptoms – if any – continue to linger. For example, Prince Charles of the United Kingdom, 71, has fully recovered from the virus. Most people recover within a few weeks, researchers from the Mayo Clinic recently wrote, “but some people – even those who have had mild versions of the disease – continue to experience symptoms after their initial recovery.”
Why are the elderly at greater risk?
Adult patients may respond to coronavirus infection with an overly vigorous adaptive immune response that may promote inflammation associated with acute respiratory distress syndrome, “a type of severe lung damage now associated with severe cases of COVID-19, according to the reports. health professionals. For example, doctors and members of the public were frightened by how otherwise strong and healthy people fell victim to the 1918 flu.
Doctors today attribute this phenomenon to the “cytokine storm” or hypercytokinemia, a process by which the immune system of healthy people reacts so strongly that it injures the body. A hallmark of some viruses: a surge of immune cells and their activating compounds (cytokines) effectively turned the body on itself and resulted in inflammation of the lungs and severe respiratory distress, leaving the body vulnerable to secondary bacterial pneumonia .
A study published last month in Science Translational Medicine, an online journal that publishes research at the intersection of science, engineering, and medicine, offered a theory as to why the immune systems of older patients ‘comes out less well. He suggested that adult patients respond to coronavirus infection with an overly vigorous, but less effective “adaptive” immune response, while children respond with a more efficient “innate” immune system.
The Dow Jones DJIA industrial index,
the S&P 500 SPX,
and the Nasdaq Composite COMP,
all closed lower Friday following the president’s diagnosis; the Nasdaq was down 2.2% at the end of the day. Doubts over the pull of another fiscal stimulus from Washington may be another factor discouraging investors who have gambled on a deal being struck by Republicans and Democrats to offer further relief.
As of Sunday, COVID-19 had killed at least 1,034,865 people worldwide and 209,749 in the United States, according to data aggregated by Johns Hopkins University. The United States still has the highest number of COVID-19 cases in the world (7,412,911), just ahead of India (6,549,373) and Brazil (4,906,833). Globally, there have been at least 35,011,322 confirmed cases, which generally does not account for asymptomatic cases.
Several companies in the United States and abroad are working on a vaccine. AstraZeneca
, in association with the University of Oxford; BioNTech SE BNTX,
and partner Pfizer PFE,
; GlaxoSmithKline GSK,
; Johnson & Johnson JNJ,
; Merck & Co. MERK,
; Moderna mRNA,
; and Sanofi SAN,
are among those working to get a vaccine through trials, with hopes that one will be read in and / or by 2021.